In vitro prooxidant effect of caffeine

Guelcin I.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, cilt.23, sa.1, ss.149-152, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 23 Sayı: 1
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1080/14756360701306404
  • Dergi Adı: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.149-152
  • Anahtar Kelimeler: caffeine, prooxidant effect, lipid peroxidation, oxidation, thiocyanate method, RADICAL SCAVENGING ACTIVITIES, ANTIOXIDANT ACTIVITY
  • Atatürk Üniversitesi Adresli: Evet

Özet

Caffeine is a methylxanthine compound that acts as a stimulant in humans. It is the most widely consumed behaviourally active substance in the western world and it affects calcium influx and release in living cells. Caffeine is present in various substances such as tea, coffee and some medications. This article is focused on the impact of caffeine on oxidation. Caffeine promoted the peroxidation of linoleic acid emulsions used by 32.5, 48.9, and 54.3%, respectively, at 15, 30 and 45 mu g/mL concentrations. Standard antioxidants such as alpha-tocopherol and trolox, a water-soluble analogue of tocopherol, inhibited 76.2 and 93.2% peroxidation of linoleic acid emulsion at 45 mu g/mL concentration. Also, PC50 value (caffeine concentration that produced a 50% increase in linoleic acid peroxidation) of caffeine was found to be 185 mu M.