The Genoprotective Activity of Resveratrol on Permethrin-Induced Genotoxic Damage in Cultured Human Lymphocytes
BRAZILIAN ARCHIVES OF BIOLOGY AND TECHNOLOGY, cilt.56, sa.3, ss.405-411, 2013 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 56 Sayı: 3
- Basım Tarihi: 2013
- Doi Numarası: 10.1590/s1516-89132013000300008
- Dergi Adı: BRAZILIAN ARCHIVES OF BIOLOGY AND TECHNOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.405-411
- Atatürk Üniversitesi Adresli: Evet
Özet
The aim of this work was to investigate the genetic effects of resveratrol (RSV) at concentrations of 10, 15, 25, 40, 75 and 100 mu M and its activities on the genotoxicity induced by the permethrin (PM) (200 mu M). After the application of PM and RSV, separately and together, cultured human lymphocytes were assessed by chromosome aberrations (CA) and sister chromatid exchange (SCE) tests. According to results, the frequencies of CA and SCE rates in the peripheral lymphocytes were significantly increased by PM compared with the controls. However, RSV had no genotoxic effect. Furthermore, the findings revealed that PM-induced increases in the mean frequencies of both genotoxic indices were diminished by RSV in a clear dose dependent manner, indicating its protective role towards the cells from PM exerted injury. In conclusion, these effects of RSV should be considered while evaluating the possible use of RSV as a therapeutic agent.