Carvacrol prodrugs as novel antimicrobial agents

Marinelli L., Fornasari E., Eusepi P., Ciulla M., Genovese S., Epifano F., ...Daha Fazla

European Journal of Medicinal Chemistry, cilt.178, ss.515-529, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 178
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1016/j.ejmech.2019.05.093
  • Dergi Adı: European Journal of Medicinal Chemistry
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.515-529
  • Anahtar Kelimeler: Antimicrobial agent, Biofilm, Carvacrol, Prodrug, BACTERIAL BIOFILMS, ESSENTIAL OILS, DERIVATIVES, PRENYLATION, INHIBITOR
  • Atatürk Üniversitesi Adresli: Hayır

Özet

Carvacrol (CAR), a natural monoterpene particularly abundant in plants belonging to the Lamiaceae family, has recently attracted much attention for its many biological properties (antioxidant, anti-inflammatory, neuroprotective, antitumour, antibacterial, and several others). However, CAR has poor chemical-physical properties (low water solubility and high volatility), which hamper its potential pharmacological uses.