Levels of some acute-phase proteins in the serum of patients with cancer during radiotherapy

KOÇ M., TAYSI S., Sezen O., Bakan N.

BIOLOGICAL & PHARMACEUTICAL BULLETIN, cilt.26, sa.10, ss.1494-1497, 2003 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26 Sayı: 10
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1248/bpb.26.1494
  • Dergi Adı: BIOLOGICAL & PHARMACEUTICAL BULLETIN
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1494-1497
  • Anahtar Kelimeler: radiotherapy, acute phase reactants, cancer, RENAL-CELL CARCINOMA, C-REACTIVE PROTEIN, CERULOPLASMIN ACTIVITY, RHEUMATOID-ARTHRITIS, TRANSFERRIN RECEPTOR, FERRITIN SYNTHESIS, IRON-DEFICIENCY, PROGNOSIS, SURVIVAL, INTERLEUKIN-6
  • Atatürk Üniversitesi Adresli: Evet

Özet

The acute phase response involves changes in serum concentrations of a number of liver-synthesized proteins. Among these are C-reactive protein (CRP), ferritin (FER), transferrin (Trf) and ceruloplasmin (Cp). Determination of serum CRP, FER, Trf, and Cp was performed in 52 patients with inoperable head and neck cancer (n=11), inoperable esophageal cancer (n=10), rectal cancer (n=9; operation was performed=5, inoperable=4), and lung cancer (n=22), all of whom were treated with radical radiotherapy (RT). Post-radiotherapy CRP levels were significantly higher compared to the preradiotherapy levels (p<0.001). We found decreased serum Trf levels during the irradiation period, while acute-phase proteins such as CRP, FER, and Cp levels increased during the RT period. Further studies on the roles of other acute phase reactants and the above mentioned parameters in a large-patients-with cancer group during radiotherapy are required to understand the role of markers, which are altered during radiotherapy.