Role of adrenal gland hormones in the anti-inflammatory effect mechanism of tamoxifen, a partial antagonist for oestrogen receptors, and relation with COX levels

Salman S., Kumbasar S., KUMTEPE Y., Karaca M., BÖREKÇİ B., Yildirim K., ...Daha Fazla

GYNECOLOGICAL ENDOCRINOLOGY, cilt.27, sa.4, ss.241-247, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 4
  • Basım Tarihi: 2011
  • Doi Numarası: 10.3109/09513590.2010.490610
  • Dergi Adı: GYNECOLOGICAL ENDOCRINOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.241-247
  • Anahtar Kelimeler: Tamoxifen, inflammation, adrenalin, corticosterone, cyclooxygenase, rat, ANTIULCER EFFECT MECHANISM, INFLAMMATION, SELECTIVITY, NIMESULIDE, STRESS
  • Atatürk Üniversitesi Adresli: Evet

Özet

Objective. There is limited study about anti-inflammatory effect mechanism of tamoxifen. We aimed to investigate the anti-inflammatory activity of tamoxifen to sec whether adrenal gland hormones have roles in the anti-inflammatory effect mechanism of tamoxifen and to evaluate the relationship between anti-inflammatory activity and cyclooxygenase (COX) level.