Synthesis of chiral sulfoximines derived from 3-aminoquinazolinones and their catalysis of enantioselective diethylzinc addition to aldehydes

Karabuga S., ÇAKICI M., KAZAZ C., ŞAHİN E., KILIÇ H., Ulukanli S.

ORGANIC & BIOMOLECULAR CHEMISTRY, cilt.9, sa.22, ss.7887-7896, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 9 Sayı: 22
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1039/c1ob06205k
  • Dergi Adı: ORGANIC & BIOMOLECULAR CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.7887-7896
  • Atatürk Üniversitesi Adresli: Evet

Özet

A series of sulfoxides were sulfoximinated using oxidative addition of 3-aminoquinazolinones by lead tetraacetate in the presence of hexamethyldisilazane. They were applied for the first time in catalytic enantioselective addition to aromatic aldehydes with a product enantiopurity (ee) of 92% in the case of 2-methoxybenzaldehyde.