Synthesis of chiral sulfoximines derived from 3-aminoquinazolinones and their catalysis of enantioselective diethylzinc addition to aldehydes
ORGANIC & BIOMOLECULAR CHEMISTRY, cilt.9, sa.22, ss.7887-7896, 2011 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 9 Sayı: 22
- Basım Tarihi: 2011
- Doi Numarası: 10.1039/c1ob06205k
- Dergi Adı: ORGANIC & BIOMOLECULAR CHEMISTRY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.7887-7896
- Atatürk Üniversitesi Adresli: Evet
Özet
A series of sulfoxides were sulfoximinated using oxidative addition of 3-aminoquinazolinones by lead tetraacetate in the presence of hexamethyldisilazane. They were applied for the first time in catalytic enantioselective addition to aromatic aldehydes with a product enantiopurity (ee) of 92% in the case of 2-methoxybenzaldehyde.