A Facile and Catalyst-free Synthesis of Hexahydroacridine-1,8(2H,5H)-dione and Octahydroacridin-10(1H)-yl)thiourea Derivatives: Inter- and Intramolecular Aza-Michael addition

Pesyan N. N., Akhteh N., Batmani H., ANIL B., ŞAHİN E.

HETEROCYCLIC COMMUNICATIONS, cilt.26, sa.1, ss.26-32, 2020 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26 Sayı: 1
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1515/hc-2020-0005
  • Dergi Adı: HETEROCYCLIC COMMUNICATIONS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core
  • Sayfa Sayıları: ss.26-32
  • Atatürk Üniversitesi Adresli: Evet

Özet

An easy and convenient technique for the one-pot synthesis of novel compounds of hexahydroacridine-1,8(2H,5H)-dione and octahydroacridin-10(1H)-yl) thiourea derivatives has been developed by the reaction of the octahydro-1H-xanthenes with hydroxylamine hydrochloride and thiosemicarbazide in ethylene glycol, which is a green solvent, under mild reaction conditions. IR, H-1 NMR, C-13 NMR spectrometry, and X-ray diffraction analysis were used to identify the structures of these compounds.