Therapeutic effects of oleuropein on cisplatin-induced pancreas injury in rats

BAKIR M., GEYİKOĞLU F., KOÇ K., Cerig S.

JOURNAL OF CANCER RESEARCH AND THERAPEUTICS, cilt.14, sa.3, ss.671-678, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 14 Sayı: 3
  • Basım Tarihi: 2018
  • Doi Numarası: 10.4103/jcrt.jcrt_1040_16
  • Dergi Adı: JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.671-678
  • Anahtar Kelimeler: Antioxidant activity, cisplatin, histopathology, oleuropein, oxidative DNA damage, pancreas, INDUCED TESTICULAR TOXICITY, OXIDATIVE STRESS, BIOLOGICAL-ACTIVITIES, OLIVE OIL, ANTIOXIDANT, MELATONIN, PREVENTS, GENOTOXICITY, POLYPHENOL, AGENT
  • Atatürk Üniversitesi Adresli: Evet

Özet

Aims: Cisplatin (CIS) is an influential chemotherapeutic agent in the treatment of several types of malignant solid tumors, but its clinical use is related with ototoxicity. Oleuropein (OLE) is a natural antioxidant and scavenging free radicals. Here, we first explore the efficacy of OLE in pancreas against to the toxicity of CIS and also analyses its mechanism.