Therapeutic effects of oleuropein on cisplatin-induced pancreas injury in rats
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS, cilt.14, sa.3, ss.671-678, 2018 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 14 Sayı: 3
- Basım Tarihi: 2018
- Doi Numarası: 10.4103/jcrt.jcrt_1040_16
- Dergi Adı: JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.671-678
- Anahtar Kelimeler: Antioxidant activity, cisplatin, histopathology, oleuropein, oxidative DNA damage, pancreas, INDUCED TESTICULAR TOXICITY, OXIDATIVE STRESS, BIOLOGICAL-ACTIVITIES, OLIVE OIL, ANTIOXIDANT, MELATONIN, PREVENTS, GENOTOXICITY, POLYPHENOL, AGENT
- Atatürk Üniversitesi Adresli: Evet
Özet
Aims: Cisplatin (CIS) is an influential chemotherapeutic agent in the treatment of several types of malignant solid tumors, but its clinical use is related with ototoxicity. Oleuropein (OLE) is a natural antioxidant and scavenging free radicals. Here, we first explore the efficacy of OLE in pancreas against to the toxicity of CIS and also analyses its mechanism.