Hypoglycaemic effect of Artemisia herba-alba in experimental hyperglycaemic rats

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Tastekin D., Atasever M., Adiguzel G., Keles M., Tastekin A.

Bulletin of the Veterinary Institute in Pulawy, cilt.50, sa.2, ss.235-238, 2006 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 50 Sayı: 2
  • Basım Tarihi: 2006
  • Dergi Adı: Bulletin of the Veterinary Institute in Pulawy
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.235-238
  • Anahtar Kelimeler: rats, Artemisia herba-alba, hypoglycaemia, hyperglycaemia, alloxan, diabetes, mellitits
  • Atatürk Üniversitesi Adresli: Evet

Özet

Artemisia herba-alba was investigated for its possible anti-diabetic effect in alloxan-induced diabetic rats. Oral administration of 0.39 g/kg b.w. of the aqueous Solution of Artemisia herba-alba exhibited a significant reduction in blood glucose content. The same effect was also seen after administration of repaglinide (1 mg/kg bw.) and regular insulin (0.1 IU/kg b.w.). It was demonstrated that the anti-diabetic effect of Artemisia herba-alba was similar to that of repaglinide and regular insulin. These results suggest that the Artemisia herba-alba possesses antidiabetic activity and is able to ameliorate biochemical damages in alloxan induced diabetes in rats.