THE EFFECT OF SUPEROXIDE-DISMUTASE AND REDUCED GLUTATHIONE ON CARDIAC-PERFORMANCE AFTER CORONARY-OCCLUSION AND REPERFUSION - AN EXPERIMENTAL-STUDY IN DOGS

KOCAK H., YEKELER I., BASOGLU A., PAC M., SENOCAK H., YUKSEK M., ...Daha Fazla

THORACIC AND CARDIOVASCULAR SURGEON, cilt.40, sa.3, ss.140-143, 1992 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 40 Sayı: 3
  • Basım Tarihi: 1992
  • Doi Numarası: 10.1055/s-2007-1020132
  • Dergi Adı: THORACIC AND CARDIOVASCULAR SURGEON
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.140-143
  • Atatürk Üniversitesi Adresli: Evet

Özet

To determine the effect of Superoxide Dismutase (SOD) and Reduced Glutathione (GSH) as free-radical scavengers on cardiac performance in the reperfusion period up to 60 minutes after occlusion of the Left Anterior Descending artery (LAD), 16 dogs were selected for study. In the 30th and 60th minutes of LAD occlusion and reperfusion periods Cardiac Output (CO), Heart Rate (HR), Mean Arterial Pressure (MAP), Pulmonary Capillary Wedge Pressure (PCWP), Coronary Perfusion Pressure (CPP), Rate Pressure Product (RPP) and Triple Index (TI) values were determined. Of the 16 dogs, 7 as controls and 7 treated with SOD and GSH could be included in the study, and 2 had to be excluded because of death. In the 30th and 60th minutes of reperfusion period, the treated dogs had higher CO and CPP (p < 0.05, p < 0.01 respectively), MAP values were different (p > 0.05, p < 0.05 respectively) from controls, whereas lower HR (p < 0.05, p > 0.05, respectively), RPP and TI values (p < 0.05) were determined.