Akademik Veri Yönetim Sistemi
Journal of Alloys and Compounds, cilt.1036, 2025 (SCI-Expanded)
Following orthopaedic and dental operations, there is a need for rapid osseointegration and complete bone formation, enabling the patient to regain mobility and progress towards full recovery. For this study, the surfaces of Ti6Al4V cortical screws were coated with a titania layer containing calcium-phosphate (Ca-P) and hydroxyapatite (HA) to ensure bioactivity, osseointegration and rapid bone formation. In order to create CaP-containing surfaces, the screws underwent plasma electrolytic oxidation (PEO) treatment in an electrolyte with Ca and P ions. This was followed by hydrothermal treatment (HT) to form the HA-containing layer. All treated and untreated screws were implanted in New Zealand albino rabbits. Then, some of the test animals were sacrificed at the end of 7 weeks, and others at the end of 18 weeks. CT examinations were achieved at the implant site before the removal of the implants, the osseointegration was measured using an electronic removal torque device and histopathological examinations were performed on the tissue at the implant removal site. The results obtained were compared with each other and with uncoated control specimens. After 7 weeks and 18 weeks of implantation, both Ca-P-containing and HA-containing surfaces showed much better results in all tests compared to control specimens. In addition, the test results of HA-containing cortical screws implanted for 7 weeks were very close to CaP-containing screws implanted for 18 weeks. The best results, however, were obtained with HA-containing screws implanted for 18 weeks. In addition to increased osteogenesis and bone resorption, these screws exhibited the highest bone formation and secondary ossification, as well as the lowest ratio of old bone tissue area compared to the others.