The protective effect of thiamine pyrophosphate but not thiamine against cardiotoxicity induced with cisplatin in rats

COŞKUN R., TURAN M. İ., TURAN I., GÜLABOĞLU M.

Drug And Chemical Toxicology, cilt.37, ss.290-294, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 37
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1177/1074248414552901
  • Dergi Adı: Drug And Chemical Toxicology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.290-294
  • Atatürk Üniversitesi Adresli: Evet

Özet

Background and Purpose: To investigate the effect of thiamine and thiamine pyrophosphate on doxorubicin-induced cardiotoxicity biochemically and histopathologically and to examine whether doxorubicin cardiotoxicity is related to the conversion of thiamine into thiamine pyrophosphate and inhibition of thiamine pyrophosphokinase (TPK) enzyme.