The protective effect of thiamine pyrophosphate but not thiamine against cardiotoxicity induced with cisplatin in rats
Drug And Chemical Toxicology, cilt.37, ss.290-294, 2014 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 37
- Basım Tarihi: 2014
- Doi Numarası: 10.1177/1074248414552901
- Dergi Adı: Drug And Chemical Toxicology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.290-294
- Atatürk Üniversitesi Adresli: Evet
Özet
Background and Purpose: To investigate the effect of thiamine and thiamine pyrophosphate on doxorubicin-induced cardiotoxicity biochemically and histopathologically and to examine whether doxorubicin cardiotoxicity is related to the conversion of thiamine into thiamine pyrophosphate and inhibition of thiamine pyrophosphokinase (TPK) enzyme.