Kratom (Mitragyna Speciosa) Alkaloids Effects on Hemodynamic and Pulmonary Measures in Obese Mice

Fields S., Shah H., Elango A., Akgün E. E., Bernstein E., Simon J., ...More

42ND ANNUAL MEETING OF THE OBESITY SOCIETY AT OBESITYWEEK, Texas, United States Of America, 03 November 2024, vol.32, pp.179, (Summary Text)

  • Publication Type: Conference Paper / Summary Text
  • Volume: 32
  • Doi Number: 10.1002/oby.24195
  • City: Texas
  • Country: United States Of America
  • Page Numbers: pp.179
  • Ataturk University Affiliated: Yes

Abstract

Kratom is derived from the leaves of Mitragyna speciosa, an evergreen tree indigenous to Southeast Asia. Kratom has been marketed for aspects of obesity management. Our goal was to exam- ine whether chronic oral dosing of a standardized alkaloid enriched- kratom extract (KE) prevented weight gain in high fat diet (HFD; 45% fat) fed mice. In addition, we examined whether acute human equiva- lent doses of KE and the major alkaloid, mitragynine (MTG), differen- tially influence cardiopulmonary measures in normal weight or obese male mice.

Kratom is derived from the leaves of Mitragyna speciosa,
an evergreen tree indigenous to Southeast Asia. Kratom has been
marketed for aspects of obesity management. Our goal was to exam-
ine whether chronic oral dosing of a standardized alkaloid enriched-
kratom extract (KE) prevented weight gain in high fat diet (HFD; 45%
fat) fed mice. In addition, we examined whether acute human equiva-
lent doses of KE and the major alkaloid, mitragynine (MTG), differen-
tially influence cardiopulmonary measures in normal weight or obese
male mice

Kratom is derived from the leaves of Mitragyna speciosa,
an evergreen tree indigenous to Southeast Asia. Kratom has been
marketed for aspects of obesity management. Our goal was to exam-
ine whether chronic oral dosing of a standardized alkaloid enriched-
kratom extract (KE) prevented weight gain in high fat diet (HFD; 45%
fat) fed mice. In addition, we examined whether acute human equiva-
lent doses of KE and the major alkaloid, mitragynine (MTG), differen-
tially influence cardiopulmonary measures in normal weight or obese
male mice

Kratom is derived from the leaves of Mitragyna speciosa,
an evergreen tree indigenous to Southeast Asia. Kratom has been
marketed for aspects of obesity management. Our goal was to exam-
ine whether chronic oral dosing of a standardized alkaloid enriched-
kratom extract (KE) prevented weight gain in high fat diet (HFD; 45%
fat) fed mice. In addition, we examined whether acute human equiva-
lent doses of KE and the major alkaloid, mitragynine (MTG), differen-
tially influence cardiopulmonary measures in normal weight or obese
male mice