Kratom (Mitragyna Speciosa) Alkaloids Effects on Hemodynamic and Pulmonary Measures in Obese Mice

Fields S., Shah H., Elango A., Akgün E. E., Bernstein E., Simon J., ...Daha Fazla

42ND ANNUAL MEETING OF THE OBESITY SOCIETY AT OBESITYWEEK, Texas, Amerika Birleşik Devletleri, 03 Kasım 2024, cilt.32, ss.179, (Özet Bildiri)

  • Yayın Türü: Bildiri / Özet Bildiri
  • Cilt numarası: 32
  • Doi Numarası: 10.1002/oby.24195
  • Basıldığı Şehir: Texas
  • Basıldığı Ülke: Amerika Birleşik Devletleri
  • Sayfa Sayıları: ss.179
  • Atatürk Üniversitesi Adresli: Evet

Özet

Kratom is derived from the leaves of Mitragyna speciosa, an evergreen tree indigenous to Southeast Asia. Kratom has been marketed for aspects of obesity management. Our goal was to exam- ine whether chronic oral dosing of a standardized alkaloid enriched- kratom extract (KE) prevented weight gain in high fat diet (HFD; 45% fat) fed mice. In addition, we examined whether acute human equiva- lent doses of KE and the major alkaloid, mitragynine (MTG), differen- tially influence cardiopulmonary measures in normal weight or obese male mice.

Kratom is derived from the leaves of Mitragyna speciosa,
an evergreen tree indigenous to Southeast Asia. Kratom has been
marketed for aspects of obesity management. Our goal was to exam-
ine whether chronic oral dosing of a standardized alkaloid enriched-
kratom extract (KE) prevented weight gain in high fat diet (HFD; 45%
fat) fed mice. In addition, we examined whether acute human equiva-
lent doses of KE and the major alkaloid, mitragynine (MTG), differen-
tially influence cardiopulmonary measures in normal weight or obese
male mice

Kratom is derived from the leaves of Mitragyna speciosa,
an evergreen tree indigenous to Southeast Asia. Kratom has been
marketed for aspects of obesity management. Our goal was to exam-
ine whether chronic oral dosing of a standardized alkaloid enriched-
kratom extract (KE) prevented weight gain in high fat diet (HFD; 45%
fat) fed mice. In addition, we examined whether acute human equiva-
lent doses of KE and the major alkaloid, mitragynine (MTG), differen-
tially influence cardiopulmonary measures in normal weight or obese
male mice

Kratom is derived from the leaves of Mitragyna speciosa,
an evergreen tree indigenous to Southeast Asia. Kratom has been
marketed for aspects of obesity management. Our goal was to exam-
ine whether chronic oral dosing of a standardized alkaloid enriched-
kratom extract (KE) prevented weight gain in high fat diet (HFD; 45%
fat) fed mice. In addition, we examined whether acute human equiva-
lent doses of KE and the major alkaloid, mitragynine (MTG), differen-
tially influence cardiopulmonary measures in normal weight or obese
male mice