Akademik Veri Yönetim Sistemi
3rd INTERNATIONAL CONFERENCE ON AGRICULTURE, FOOD, VETERINARY AND PHARMACY SCIENCES, Bayrut, Lübnan, 10 - 12 Kasım 2023, ss.237-250
This
study investigates the extraction yields, phenolic and flavonoid contents,
antioxidant capacities, and potential antidiabetic effects of various solvent
extracts from Datura innoxia Mill. seeds. The extraction yields revealed
that hexane (HEX), ethyl acetate (ETA), and methanol (MET) extracts had the
highest yield, while butanol (BUT) and aqueous (AE) extracts had lower yield.
Phenolic content was highest in the ETA and AE extracts, while the lowest was
observed in the HEX extract. In contrast, flavonoid content increased with
solvent polarity, with AE exhibiting the highest content. Antioxidant capacity
revealed that the AE extract exhibited high ABTS.+ radical
scavenging activity, while MET and HEX extracts also displayed significant
activity. DPPH. scavenging activity was strongest in the AE extract and showed a dose-dependent
increase in the HEX and ETA extracts. Superoxide radical scavenging activity was
primarily found in the MET, HEX, and AE extracts. Additionally, the extracts
displayed potent ferric reducing antioxidant power (FRAP), especially the MET,
AE, and BUT extracts. The antidiabetic potential of the extracts was evaluated
in an animal model. While higher doses of extracts did not significantly affect
blood glucose levels, 50 mg/mL AE and MET extracts demonstrated a temporary
decrease in plasma glucose. The extracts also appeared to have a positive
effect on diabetic rats' survival. It was suggested that MET, BUT, and AE extracts
obtained from D. innoxia seeds exhibited strong antioxidant properties,
with the MET extract, in particular, able to alleviate hyperglycemic effects in
the STZ-induced diabetic rats.