Synthesis and anticancer properties of mono Mannich bases containing vanillin moiety

TUĞRAK M., GÜL H. İ., SAKAGAMI H., METE E.

MEDICINAL CHEMISTRY RESEARCH, cilt.26, sa.7, ss.1528-1534, 2017 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26 Sayı: 7
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1007/s00044-017-1833-x
  • Dergi Adı: MEDICINAL CHEMISTRY RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1528-1534
  • Anahtar Kelimeler: Mannich bases, Cytotoxicity, Vanillin, Methoxy group, Selectivity, ANTIINFLAMMATORY ACTIVITY, BIOLOGICAL EVALUATION, CELLULAR GLUTATHIONE, CYTOTOXIC ACTIVITIES, JURKAT CELLS, DERIVATIVES, BIS, ACETOPHENONE, BIOASSAY, ANALOGS
  • Atatürk Üniversitesi Adresli: Evet

Özet

In this study, Mannich bases 2-8, 2-(3-or-5-aminomethyl-4-hydroxy-3-or-5-methoxybenzylidene)indan-1-one, were designed and synthesized starting from 2-(4-hydroxy-3-methoxybenzylidene)indan-1-one, 1. Synthesized compounds were tested against several tumor cell lines and non-tumor cells to evaluate the cytotoxicities of the compounds and to test whether the sequential cytotoxicity hypothesis works on the studied compounds. The data obtained from cytotoxicity tests pointed out that sequential cytotoxicity hypothesis worked on compounds 3 and 4 since they had higher potency selectivity expression values. The leader compound of the present study is compound 4, 2-(3-dipropylaminomethyl-4-hydroxy-5-methoxy-benzylidene)-indan-1-one, since it has the highest potency selectivity expression value among the compounds studied. This molecule can be the leader compound for further studies and designes.