Fluorescein-entrapped magnetosomes for magnetically assisted photodynamic therapy
Nanomedicine, cilt.16, sa.11, ss.883-894, 2021 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 16 Sayı: 11
- Basım Tarihi: 2021
- Doi Numarası: 10.2217/nnm-2020-0445
- Dergi Adı: Nanomedicine
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, PASCAL, BIOSIS, Biotechnology Research Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE
- Sayfa Sayıları: ss.883-894
- Anahtar Kelimeler: fluorescein, in vitro cytotoxicity, magnetic targeting, magnetosomes, photodynamic therapy
- Atatürk Üniversitesi Adresli: Hayır
Özet
Aim: We investigated the application of fluorescein (FL)-entrapped magnetosomes, in other words, silica-coated iron oxide nanoparticles entrapped within niosomes (SIO/NIO), in magnetically assisted photodynamic therapy (PDT) in vitro. Methods: Panc-1 cells were treated with the magnetosomes, with and without external magnetic guidance, and irradiated with blue light. Results & conclusion: Upon photoactivation, the FL-entrapped magnetosomes can produce higher singlet oxygen in comparison to FL-entrapped micelles, probably due to the higher release tendency of the photosensitizer from the former. In vitro studies in Panc-1 cells revealed magnetically assisted enhancement in the cellular uptake of the magnetosomes. Magnetic assistance also led to enhancement in PDT efficiency in cells treated with the FL-entrapped magnetosomes and light, thus highlighting their potential in PDT.