Differentially regulated ADAMTS1, 8, 9, and 18 in pancreas adenocarcinoma

Kilic, Murat; Aynekin, Busra; Bozer, Mikdat; KARA, Adem; Haltas, Hacer; İÇEN, DUYGU; Demircan, Kadir

doi:10.5114/pg.2017.72101

Differentially regulated ADAMTS1, 8, 9, and 18 in pancreas adenocarcinoma

Kilic M. O., Aynekin B., Bozer M., KARA A., Haltas H., İÇEN D., ...Daha Fazla

GASTROENTEROLOGY REVIEW-PRZEGLAD GASTROENTEROLOGICZNY, cilt.12, sa.4, ss.262-270, 2017 (ESCI, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 12 Sayı: 4
Basım Tarihi: 2017
Doi Numarası: 10.5114/pg.2017.72101
Dergi Adı: GASTROENTEROLOGY REVIEW-PRZEGLAD GASTROENTEROLOGICZNY
Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
Sayfa Sayıları: ss.262-270
Atatürk Üniversitesi Adresli: Evet

Özet

Introduction: Despite recent diagnostic and therapeutic improvements, pancreas cancer remains one of the highly lethal cancers. The extracellular matrix (ECM) is a physiological barrier that limits the spread of cancer cells into surrounding tissues and distant organs. Disintegrin and metalloprotease with thrombospondin motifs (ADAMTS) is a family of 19 proteases, which is involved in various biological processes such as ECM remodelling and anti-angiogenesis.