The main aim of this study is to conduct the period of training of active athletes competitions blood lipids (triglycerides, cholesterol) and lipoprotein (HDL-C, LDL-C and VLDL) changes in levels of malondialdehyde (MDA) and glutathione peroxides (GPX) levels and to investigate the related effects in this regard. The research group is consisted of twenty volunteer athletes participated in seasonal training within the program of training sessions on a regular basis. Blood samples were taken at the end of the season and before the competition season and plasma MDA, GPX serum, blood lipids and lipoproteins were analyzed in this case. According to the working group cases for the comparison of pre-and post-test analysis of HDL-C (p <0.05) and GPX (p <0.01), significantly differences in the related research were found. Competition of post-MDA levels in serum TG, VLDL and p <0.01 was showed difference between the levels. As a result, the working group making a regular practice of lipid peroxidation did not increase due to the adaptation of MDA in understanding the changes. GPX-s recent emergence is due to the cause of low measurements and the fact that athletes could be considered as having an adequate antioxidant defense system.