New Synthetic Methodology for Construction of the 1,3,4,5-Tetrahydro-2H-1,3-benzodiazepin-2-one Skeleton
SYNTHESIS-STUTTGART, sa.8, ss.1365-1370, 2010 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Basım Tarihi: 2010
- Doi Numarası: 10.1055/s-0029-1218673
- Dergi Adı: SYNTHESIS-STUTTGART
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1365-1370
- Anahtar Kelimeler: acyl azide, isocyanate, Curtius rearrangement, urethanes, benzodiazepinone, SELENIUM-ASSISTED CARBONYLATION, CYCLIC UREAS, BENZODIAZEPINE, CHEMISTRY, ACID
- Atatürk Üniversitesi Adresli: Evet
Özet
We hereby report a new synthetic methodology for construction of the 1,3,4,5-tetrahydro-2H-1,3-benzodiazepin-2-one skeleton. 2-(2-Carboxyethyl)benzoic acid was converted into the corresponding bis(acyl azide). Curtius rearrangement of the diazide followed by reaction with alcohols provided diurethane derivatives. Ring-closure reaction of the diurethanes with base resulted in formation of the 1,3-benzodiazepin-2-one skeleton.