Akademik Veri Yönetim Sistemi
Beyoglu Eye Journal, cilt.5, sa.3, ss.219-222, 2020 (Hakemli Dergi)
Objectives: Carvacrol (CV) is a phenolic monoterpenoid found in the essential oil of a number of aromatic plants and
herbs. The present study was an investigation of the potential protective effect of CV against paclitaxel (PTX)-induced
retinal and optic nerve cytotoxicity in rats.
Methods: A total of 18 adult male Wistar albino rats (250-400g) were randomized into 3 equal groups comprising 6 animals each. Group 1 (control group) received intraperitoneal (IP) saline solution (0.5 mL/200 g) weekly for 4 weeks. Group
2 received an IP dose of PTX (5 mg/kg), and Group 3 received CV (25 mg/kg) 30 minutes after an IP dose of PTX (5 mg/
kg) weekly for 4 weeks. At the conclusion of the experimental period, the retinal and optic nerve tissues of the subjects
were evaluated histopathologically.
Results: All of the retinal specimens in Group 1 (control) were histopathologically normal. In Group 2 (PTX), all of
the eyes (6/6) revealed increased retinal vascularity and rosette-like structures in the outer nuclear layer, and in Group
3 (PTX-CV), all of the eyes (6/6) demonstrated normal retinal vascularity and the absence of rosette-like structures. All
of the optic nerve specimens in Group 1 (control) were histopathologically normal. In Group 2 (PTX), all of the eyes
(6/6) demonstrated severe vacuolization and a decreased number of astrocytes and oligodendrocytes in the optic nerve
specimens, while 3 eyes (3/6) showed marked single cell necrosis. None of the eyes in Group 3 (PTX-CV) demonstrated
either vacuolization or a reduction in the number of astrocytes and oligodendrocytes. No remarkable single cell necrosis
was observed in the optic nerve specimens of Group 3 (PTX-CV).
Conclusion: The histopathological findings indicated that CV played a protective role against PTX-induced cytotoxicity.
CV might be a promising resource to counteract oxidative stress-based cytotoxicity in the field of retinal and optic nerve
disorders