Akademik Veri Yönetim Sistemi
Istanbul Tip Fakultesi Dergisi, cilt.88, sa.1, ss.53-59, 2025 (ESCI)
Objective: Mycosis fungoides (MF) is the most common T-cell skin lymphoma, and a simple and applicable parameter is needed to monitor the prognosis of the disease. We investigated the ratio of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in patients with MF. Material and Methods: The research involved a retrospective, cross-sectional study. The records of MF patients were analysed. AST and ALT levels were recorded and the AST/ALT ratio was calculated and compared with the control group. Results: Eighty-five MF patients and 85 healthy controls were included in the study. Males accounted for 56.5% (n=48) of MF patients and 57.6 % (n=49) of healthy group, with no significant difference (p>0.05) between them. AST levels were notably elevated in the MF group compared with the healthy group (p<0.001). Furthermore, there was a significant difference in the AST/ALT ratio between the two groups (p=0.005). The AST/ALT ratio cut-off value was 1.067. The AST value in the patients with abnormal lymphadenopathy (LAP) on ultrasonography (USG) was higher than in those with reactive LAP. The AST values of the patients with LAP with fluorodeoxyglucose (FDG) involvement on positron emission tomography (PET)/computed tomography (CT) were significantly higher than those of the patients without abnormal LAPs (p<0.05). The AST/ALT ratio was weakly positively correlated with the disease stage (p=0.018). Conclusion: AST values and AST/ALT ratios of patients with MF were significantly higher than those of the control group. The AST/ALT ratio can be used as an independent factor in monitoring the prognosis of patients with MF.