Aminoalkylated Phenolic Chalcones: Investigation of Biological Effects on Acetylcholinesterase and Carbonic Anhydrase I and II as Potential Lead Enzyme Inhibitors

Yamali C., GÜL H. İ., Çakır T., Demir Y., GÜLÇİN İ.

LETTERS IN DRUG DESIGN & DISCOVERY, cilt.17, sa.10, ss.1283-1292, 2020 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Sayı: 10
  • Basım Tarihi: 2020
  • Doi Numarası: 10.2174/1570180817999200520123510
  • Dergi Adı: LETTERS IN DRUG DESIGN & DISCOVERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Agricultural & Environmental Science Database, Biotechnology Research Abstracts, EMBASE
  • Sayfa Sayıları: ss.1283-1292
  • Anahtar Kelimeler: Mannich, chalcone, carbonic anhydrases, acetylcholinesterase, phenol, hCA I, hCA II, MANNICH BASE DERIVATIVES, MULTIFUNCTIONAL AGENTS, HCA IX, BIOACTIVITIES, CYTOTOXICITY, APOPTOSIS, DESIGN
  • Atatürk Üniversitesi Adresli: Evet

Özet

Background: Phenolic Mannich bases have been reported as acetylcholinesterase (AChE) inhibitors for the medication of Alzheimer's disease. Carbonic Anhydrases (CAs) are molecular targets for anticonvulsant, diuretic and antiglaucoma drugs in the clinic. Phenolic compounds have also been mentioned as CA inhibitors. The importance of Mannich bases in drug design inspired our research group to design novel phenolic Mannic bases as potent enzyme inhibitors.