Akademik Veri Yönetim Sistemi
5th International Conference on Natural Products for Cancer Preventation and Therapy, Nevşehir, Türkiye, 7 - 09 Haziran 2024, (Yayınlanmadı)
Cousinia birandiana is one of the species
of the Cousinia genus from the Asteraceae family. This species is
endemic to Turkey and there are few studies on the pharmacological effects and
phytochemical content. In the current study, the 70% ethanol extract and n-hexane,
ethyl acetate, n-butanol, and water fractions from this plant were investigated
for their cytotoxic activity against DU-145 (human brain metastatic prostate
cancer), HeLa (human cervix cancer) and MCF-7 (human estrogen positive breast
cancer) cell lines by the MTT method after 24 h of treatment. In this study, cisplatin
was used as a positive control, which has been widely used in the treatment of
a range of cancers. According to the results, all the tested extracts showed
cytotoxicity in a dose-dependent manner. However, the ethyl acetate fraction was
found to be the most active with 78.86±1.896 μg/mL, 78.02±2.173 μg/mL, and
44.28±3,31 μg/mL IC50 values against DU-145, HeLa, and MCF-7 cell
lines, respectively. In conclusion, it is the first cytotoxic
activity study with C. birandiana species, and our future studies
will focus on cytotoxicity tests on other cancerous and healthy cell lines.