Phytochemical analysis and biological evaluation of essential oils and extracts from <i>Heracleum pastinacifolium</i> subsp. <i>incanum</i> (Boiss. & A.Huet) PHDavis, an endemic plant from Turkey

YUCA H., SEFALI A., AYDIN B., KARADAYI M., Gulsahin Y., YAZICI A., ...Daha Fazla

NATURAL PRODUCT RESEARCH, cilt.39, sa.22, ss.6421-6431, 2025 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 39 Sayı: 22
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1080/14786419.2024.2372661
  • Dergi Adı: NATURAL PRODUCT RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Aquatic Science & Fisheries Abstracts (ASFA), Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, CINAHL, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.6421-6431
  • Anahtar Kelimeler: Alzheimer’s, diabetes, genotoxic, Heracleum pastinacifolium subsp. incanum, hesperidin, myristicine
  • Atatürk Üniversitesi Adresli: Evet

Özet

Essential oil content of and phenolic compounds flower-fruit, root, and aerial parts of Heracleum pastinacifolium subsp. incanum were analysed by GC/MS and LC/MS methods, respectively. Antidiabetic, anticholinesterase, and antioxidant activities of flower-fruit, root, aerial parts methanol extracts were evaluated. Apiole (35.0%), myristicine (72.2%), and myristicine (15.1%) were found as major compounds of fruit-flower mixture, root, aerial part essential oils, respectively. Hesperidin was found the highest amount in aerial part and flower-fruit extracts with 8904.2621 ng/mL and 11558.3634 ng/mL values, respectively. Fruit-flower extract showed the highest activity against alpha-glucosidase (24%). Root extract demonstrating the highest activity (18%) against AChE enzyme. Flowers-fruits mixture methanol extract had a higher % inhibition value on ABTS(+) and DPPH center dot. Flowers-fruits mixture methanol extract was rich in total phenol, total tannin, and protein content. All the extracts were determined as genetoxically safe according to the results of Ames/Salmonella, Escherichia coli WP2 and Allium cepa assays.