Preliminary investigation of gene expression levels of PAPP-A, STC-2, and HIF-1 alpha in SARS-Cov-2 infected patients

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Uzuncakmak S. K., Naldan M. E., Dirican E., Kerget F., HALICI Z.

MOLECULAR BIOLOGY REPORTS, cilt.49, sa.9, ss.8693-8699, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 49 Sayı: 9
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1007/s11033-022-07710-9
  • Dergi Adı: MOLECULAR BIOLOGY REPORTS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.8693-8699
  • Anahtar Kelimeler: SARS-CoV-2, PAPP-A, STC-2, HIF-1 alpha, COVID-19, PLASMA-PROTEIN-A, HYPOXIA-INDUCIBLE FACTOR, BINDING PROTEIN-4, STANNIOCALCIN-2, TARGET, CELLS, GROWTH, INHIBITION, MOUSE, HIF-1
  • Atatürk Üniversitesi Adresli: Evet

Özet

Background Coronavirus-19 is still considered a pandemic that influences the world. Other molecular alterations should be clearer besides the increasing cytokine storm and pro-inflammatory molecules. Hypoxic conditions that induce HIF-1 alpha lead to stimulate gene expression of STC-2 that targets PAPP-A expression. This study aimed to determine gene expression levels of PAPP-A, STC-2, and HIF-1 alpha in COVID-19 infection. We also aimed to reveal the relationship of these genes with laboratory and clinical data of COVID-19 patients.