Preliminary investigation of gene expression levels of PAPP-A, STC-2, and HIF-1 alpha in SARS-Cov-2 infected patients
MOLECULAR BIOLOGY REPORTS, cilt.49, sa.9, ss.8693-8699, 2022 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 49 Sayı: 9
- Basım Tarihi: 2022
- Doi Numarası: 10.1007/s11033-022-07710-9
- Dergi Adı: MOLECULAR BIOLOGY REPORTS
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Veterinary Science Database
- Sayfa Sayıları: ss.8693-8699
- Anahtar Kelimeler: SARS-CoV-2, PAPP-A, STC-2, HIF-1 alpha, COVID-19, PLASMA-PROTEIN-A, HYPOXIA-INDUCIBLE FACTOR, BINDING PROTEIN-4, STANNIOCALCIN-2, TARGET, CELLS, GROWTH, INHIBITION, MOUSE, HIF-1
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Atatürk Üniversitesi Adresli: Evet
Özet
Background Coronavirus-19 is still considered a pandemic that influences the world. Other molecular alterations should be clearer besides the increasing cytokine storm and pro-inflammatory molecules. Hypoxic conditions that induce HIF-1 alpha lead to stimulate gene expression of STC-2 that targets PAPP-A expression. This study aimed to determine gene expression levels of PAPP-A, STC-2, and HIF-1 alpha in COVID-19 infection. We also aimed to reveal the relationship of these genes with laboratory and clinical data of COVID-19 patients.