Preventive role of folic acid on the developmental toxicity of phenol in Drosophila melanogaster

AŞKIN H., UYSAL H., Altun D.

TOXICOLOGY AND INDUSTRIAL HEALTH, cilt.23, sa.10, ss.591-598, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 23 Sayı: 10
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1177/0748233708090905
  • Dergi Adı: TOXICOLOGY AND INDUSTRIAL HEALTH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.591-598
  • Anahtar Kelimeler: Drosophila melanogaster, folic acid, phenol, preventive effect, toxicity, NEURAL-TUBE, ANTIOXIDANT ACTIVITY, DERMAL EXPOSURE, FOLATE, CELLS, DEFECTS, INVITRO, TETRAHYDROFOLATE, SUPPLEMENTATION, HYDROQUINONE
  • Atatürk Üniversitesi Adresli: Evet

Özet

Phenol (PN), obtained from coal tar, is used commonly in medical treatments, industrial areas, petroleum refineries, production of glue, fiber, and nylon. PN is,,used in the production of benzene and it is emitted in the atmosphere by motor vehicles. Folic acid (FA) is an essential nutrient among the B complex group of vitamins. The main aim of this study was to investigate the effects of PN and PN + FA on various developmental stages of Drosophila melanogaster. Different concentrations of PN and PN + FA were administered during the developmental periods of the fly (egg, larva and pupa). When F, progeny of control and experimental groups were compared, PN was found to extend the process of metamorphosis and decrease the total offspring numbers. However, these negative effects were inhibited by FA treatment at different concentrations (0.25-2.50 mg/kg). These results suggest that FA could effectively inhibit PN-induced abnormalities in developmental stages of Drosophila melanogaster.