Effects of levetiracetam monotherapy on sperm parameters and sex hormones: Data from newly diagnosed patients with epilepsy

Ceylan M., YALÇIN A., BAYRAKTUTAN O. F., KARABULUT I., SONKAYA A. R.

SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, cilt.41, ss.70-74, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 41
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1016/j.seizure.2016.06.001
  • Dergi Adı: SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.70-74
  • Anahtar Kelimeler: Epilepsy, Levetiracetam, Spermiogram, Sex hormones, ANTIEPILEPTIC DRUGS, PITUITARY-RESPONSIVENESS, TEMPORAL-LOBE, WISTAR RATS, CARBAMAZEPINE, MEN, VALPROATE, CELLS, EXPRESSION, PHENYTOIN
  • Atatürk Üniversitesi Adresli: Evet

Özet

Purpose: Epilepsy has an impact on the reproductive system. Males with epilepsy have lower fertility rates, hypo-sexuality and reduced potency compared with the general population. Anti-epileptic drugs and epilepsy itself are thought to be responsible for this reduced fertility. LEV is a second-generation anti-epileptic agent with low incidences of both adverse effects and drug-drug interactions. In this study, we have investigated the effects of LEV treatment on sex hormones and sperm parameters in newly diagnosed epilepsy patients.