Akademik Veri Yönetim Sistemi
FLORA INFEKSIYON HASTALIKLARI VE KLINIK MIKROBIYOLOJI DERGISI, cilt.30, sa.1, ss.42-52, 2025 (ESCI, TRDizin)
Introduction: Human immunodeficiency virus (HIV) infection remains one of the most significant global health challenges, with an increasing prevalence observed in our country. Although antiretroviral therapy (ART) effectively controls the virus, chronic inflammation continues throughout life. This retrospective study evaluated the epidemiological, clinical, and laboratory findings of HIV/acquired immunodeficiency syndrome (AIDS) cases followed in our clinic between 2008 and 2023, as well as the relationship between HIV and the systemic immune-inflammation index (SIII). Materials and Methods: The study included 190 HIV/AIDS patients aged 18 years and above who were followed in our center between January 2009 and January 2024. The sociodemographic characteristics, clinical, treatment, and laboratory data of the patients were obtained retrospectively from patient files and the hospital automation system. SIII values were calculated using the formula: "peripheral blood platelet count x neutrophil count/lymphocyte count". Laboratory and SIII values of the patients were compared before and after treatment. Results: Of the patients, 81.6% were male and the mean age was 36.44 +/- 11.7 years. The mean pre-treatment CD4 level was 485.34 +/- 322.66 cells/mm(3) and the median HIV-RNA value was 138.500 IU/mL. When LDL cholesterol levels were compared with patients with pre-treatment and treatment duration <1 year, it was observed that they decreased significantly and HDL cholesterol levels increased significantly (p= 0.005, p= 0.04, respectively). There was a decrease in SIII values as CD4 levels increased. The difference between stages 1 and 2 and stages 1 and 3 was statistically significant (p values; 0.011, 0.001, respectively). At the time of presentation, 11 (5.7%) patients were diagnosed with malignancy and the most common co-infections were syphilis (19.5%) and hepatitis B (3.5%). SIII values were significantly higher in patients with opportunistic infections than those without (p= 0.002). The most commonly initiated and maintained ART regimen was tenofovir disoproxil/emtricitabine/dolutegravir. Conclusion: HIV infection remains a significant public health concern in our country, with the number of cases continuing to rise daily. Despite the viral suppression and immunological response achieved through effective ART, chronic inflammation persists.