Evaluation of 5-HT7 receptor expression in the placentae of normal and pre-eclamptic women

IRGE E., HALICI Z., YILMAZ M., ÇADIRCI E., Karakus E.

CLINICAL AND EXPERIMENTAL HYPERTENSION, cilt.38, sa.2, ss.189-193, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 38 Sayı: 2
  • Basım Tarihi: 2016
  • Doi Numarası: 10.3109/10641963.2015.1081215
  • Dergi Adı: CLINICAL AND EXPERIMENTAL HYPERTENSION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.189-193
  • Anahtar Kelimeler: 5-HT, placenta, 5-HT7 receptor, pre-eclampsia, PREGNANCY-INDUCED HYPERTENSION, SEROTONIN, 5-HYDROXYTRYPTAMINE, INFLAMMATION, HISTAMINE, ARTERIES, PATHOGENESIS, ANTAGONIST, MECHANISMS, CYTOKINES
  • Atatürk Üniversitesi Adresli: Evet

Özet

In this study, by examining 5-HT7 receptor expression in placentae from pre-eclamptic and normal pregnancies, we aimed to discover a new step of pathophysiological cascade for preeclampsia. Patients whose blood pressure over the 140/90 mmHg were included when study after 20 weeks of gestation. 5-HT7 receptor expression was investigated on the placentae obtained after birth by real time PCR (RT-PCR) analysis. Pre-natal-post-natal, systolic-diastolic blood pressure values, proteinuria and renal function indicators as BUN and creatinine levels of pre-eclamptic pregnant women were higher than the healthy group. Similarly, 5-HT7 receptor expression determined in healthy placentae increased 8-fold in pre-eclamptic women. This study, for the first time we showed 5-HT7 receptor expression in normal placenta and increased expression in pre-eclamptic placenta.