Biotransformation of racemic diisophorone by Cephalosporium aphidicola and Neurospora crassa

Kiran I., Akar T., Gorgulu A., Kazaz C.

BIOTECHNOLOGY LETTERS, cilt.27, sa.14, ss.1007-1010, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 14
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1007/s10529-005-7868-y
  • Dergi Adı: BIOTECHNOLOGY LETTERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1007-1010
  • Anahtar Kelimeler: Cephalosoporium aphidicola, diisophorone, hydroxylation, Neurospora crassa, RESISTANCE
  • Atatürk Üniversitesi Adresli: Evet

Özet

Racemic diisophorone (500 mg) was converted by Cephalosporium aphidicola and Neurospora crassa over 10 days at 25 degrees C to 8 beta-hydroxydiisophorone in yields of 10% (52 mg) and 20% (103 mg), respectively. The structure was established by IR, specific rotation, mass spectral, 1D and 2D-NMR studies.