Determination of antimutagenic properties of apigenin-7-O-rutinoside, a flavonoid isolated from Mentha longifolia (L.) Huds. ssp longifolia with yeast DEL assay

GÜLLÜCE M., ORHAN F., ADIGÜZEL A., Bal T., GÜVENALP Z., Dermirezer L. O.

TOXICOLOGY AND INDUSTRIAL HEALTH, cilt.29, sa.6, ss.534-540, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 29 Sayı: 6
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1177/0748233712442732
  • Dergi Adı: TOXICOLOGY AND INDUSTRIAL HEALTH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.534-540
  • Anahtar Kelimeler: Antimutagenicity, yeast DEL assay, apigenin, Mentha longifolia, Saccharomyces cerevisiae RS112, HAMSTER V79 CELLS, INTRACHROMOSOMAL RECOMBINATION, ANTIOXIDANT ACTIVITY, DNA-DAMAGE, CARCINOGENS, GENOTOXICITY, EXTRACTS
  • Atatürk Üniversitesi Adresli: Evet

Özet

Lamiaceae is an important plant family that has been investigated for its medicinal properties due to its large amounts of phenolic acids and flavonoids. Flavonoids have been shown to have antioxidant and antimutagenic activities in different test systems, but their certain mechanisms are still unclear. This study was designed to evaluate the mutagenic and antimutagenic activities of apigenin 7-O-rutinoside, a flavonoid isolated from Mentha longifolia (L.) Huds. ssp. longifolia. The possible antimutagenic potential of apigenin 7-O-rutinoside (A7R) was examined against mutagens ethyl methanesulfonate (EMS) and acridine (AC) in a eukaryotic cell system Saccharomyces cerevisiae RS112. The results showed that A7R has different inhibition rates against EMS and AC-induced mutagenicity. Thus, the properties of A7R are of great pharmacological importance and might be beneficial for reducing the risk of reactive oxygen species-related diseases.