Akademik Veri Yönetim Sistemi
LIFE-BASEL, cilt.13, sa.11, 2023 (SCI-Expanded)
Baicalin is the foremost prevalent flavonoid found in Scutellaria baicalensis. It also frequently occurs in many multi-herbal preparations utilized in Eastern countries. The current research has assessed and compared the antioxidant, antidiabetic, anticholinergic, and antiglaucoma properties of baicalin hydrate. Baicalin hydrate was tested for its antioxidant capacity using a variety of techniques, including N,N-dimethyl-p-phenylenediamine dihydrochloride radical (DMPD center dot+) scavenging activity, 2,2 '-azinobis-(3-ethylbenzothiazoline-6-sulphonate) radical (ABTS(center dot+)) scavenging activity, 1,1-diphenyl-2-picrylhydrazyl radical (DPPH center dot) scavenging activity, potassium ferric cyanide reduction ability, and cupric ions (Cu2+) reducing activities. Also, for comparative purposes, reference antioxidants, such as butylated hydroxyanisole (BHA), Trolox, alpha-Tocopherol, and butylated hydroxytoluene (BHT) were employed. Baicalin hydrate had an IC50 value of 13.40 mu g/mL (r(2): 0.9940) for DPPH radical scavenging, whereas BHA, BHT, Trolox, and alpha-Tocopherol had IC50 values of 10.10, 25.95, 7.059, and 11.31 mu g/mL for DPPH center dot scavenging, respectively. These findings showed that baicalin hydrate had comparably close and similar DPPH center dot scavenging capability to BHA, alpha-tocopherol, and Trolox, but it performed better than BHT. Additionally, apart from these studies, baicalin hydrate was tested for its ability to inhibit a number of metabolic enzymes, including acetylcholinesterase (AChE), butyrylcholinesterase (BChE), carbonic anhydrase II (CA II), and alpha-glycosidase, which have been linked to several serious illnesses, such as Alzheimer's disease (AD), glaucoma, and diabetes, where the K-i values of baicalin hydrate toward the aforementioned enzymes were 10.01 +/- 2.86, 3.50 +/- 0.68, 19.25 +/- 1.79, and 26.98 +/- 9.91 nM, respectively.