Mitochondrial homeostasis in heart failure with preserved ejection fraction: from metabolic remodeling to multi-organ crosstalk
Journal of Cardiovascular Aging, cilt.6, sa.3, 2026 (ESCI, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 6 Sayı: 3
- Basım Tarihi: 2026
- Doi Numarası: 10.20517/jca.2026.84
- Dergi Adı: Journal of Cardiovascular Aging
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
- Anahtar Kelimeler: HFpEF, mitochondrial, homeostasis, metabolic, remodeling, oxidative stress
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Atatürk Üniversitesi Adresli: Evet
Özet
Heart failure with preserved ejection fraction (HFpEF) represents a predominant heart failure phenotype characterized by intricate pathophysiology and an escalating global prevalence. Beyond classical hemodynamic disturbances, emerging evidence identifies mitochondrial dysfunction as a central mechanism in HFpEF pathogenesis. This review synthesizes the pivotal mitochondrial aberrations driving HFpEF, including impaired bioenergetics, disrupted mitochondrial quality control, oxidative stress, and Ca2+ dyshomeostasis, particularly under the burden of cardiometabolic stressors. Importantly, we highlight that HFpEF represents a multisystem disorder wherein the mitochondria of adipose tissue, the vasculature, the immune system, and skeletal muscle actively contribute to the pathological process. By reclassifying HFpEF as a bioenergetic failure, we hope to provide a conceptual framework for the development of integrated, mitochondria-targeted therapeutic strategies.