The protective effects of hesperidin pretreatment on kidney and remote organs against renal ischemia-reperfusion injury

Karacaer C., Erdogan D. G., TANYELİ A., Baylan H., ERASLAN E., GÜLER M. C., ...Daha Fazla

EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, cilt.27, sa.7, ss.2808-2814, 2023 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 7
  • Basım Tarihi: 2023
  • Doi Numarası: 10.26355/eurrev_202304_31911
  • Dergi Adı: EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, Directory of Open Access Journals
  • Sayfa Sayıları: ss.2808-2814
  • Anahtar Kelimeler: Hesperidin, Renal ischemia-reperfusion, Injury, Remote organ, Lung, NF-KAPPA-B, ASSAY
  • Atatürk Üniversitesi Adresli: Evet

Özet

OBJECTIVE: As an antioxidant and anti-inflammatory agent, Hesperidin was in-vestigated to prove whether it prevents damage to the kidney and lung tissues of rats undergo-ing renal ischemia-reperfusion injury.MATERIALS AND METHODS: Four groups of rats were set, including eight subjects each as Group 1 (control), Group 2-RIR (renal isch-emia reperfusion), Groups 3 and 4 as pretreat-ment groups (50 HES, 100 HES).RESULTS: According to our results, Hesperi-din pretreatment improved the biochemical and histopathological parameters in kidney and lung tissues of rats with ischemia-reperfusion injury. Besides, a 100 mg/kg dose of Hesperidin was found to be more beneficial to the rats than 50 mg/kg.CONCLUSIONS: The study suggests that Hesperidin is protective against renal and lung tissues of rats that underwent ischemia-reper-fusion injury.