Treatment of malignant gliomas with mitoxantrone-loaded poly (lactide-co-glycolide) microspheres

Yemıscı M., Bozdag S., Cetin M., Söylemezoglu F., Capan Y., Dalkara T., ...Daha Fazla

NEUROSURGERY, cilt.59, sa.6, ss.1296-1302, 2006 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 59 Sayı: 6
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1227/01.neu.0000245607.99946.8f
  • Dergi Adı: NEUROSURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1296-1302
  • Anahtar Kelimeler: high-performance liquid chromatography, malignant glioma, microspheres, mitoxantrone, poly(lactide-co-glycolide), rat glioma cells, RG2 cells, INJECTABLE CHEMOTHERAPEUTIC MICROSPHERES, SURVIVAL FOLLOWING IMPLANTATION, CULTURED MAMMALIAN-CELLS, BRAIN-TUMORS, CONTROLLED-RELEASE, DRUG-DELIVERY, IN-VITRO, BIODEGRADABLE MICROSPHERES, INTERSTITIAL CHEMOTHERAPY, ALBUMIN MICROSPHERES
  • Atatürk Üniversitesi Adresli: Evet

Özet

OBJECTIVE: Mitoxantrone (MTZ) has potent in vitro activity against malignant glioma cell lines, but it,cannot be used effectively as a systemic agent for the treatment of brain tumors because of its poor central nervous system penetration. However, MTZ-loaded poly(lactide-co-glycolide) (PLGA) microspheres may be injected into the peritumoral area and into tumor tissue to provide effective and sustained local drug concentrations without causing systemic side effects.