The effects of zingerone against vancomycin-induced lung, liver, kidney and testis toxicity in rats: The behavior of some metabolic enzymes

Caglayan C., Taslimi P., Demir Y., Küçükler S., Kandemir F. M., Gülçin İ.

Journal of Biochemical and Molecular Toxicology, cilt.33, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1002/jbt.22381
  • Dergi Adı: Journal of Biochemical and Molecular Toxicology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: acetylcholinesterase, aldose reductase, carbonic anhydrase, vancomycin, zingerone, CARBONIC-ANHYDRASE ACTIVITY, INDUCED OXIDATIVE STRESS, INHIBITION PROFILES, ACUTE EXPOSURE, ACETYLCHOLINESTERASE, INFLAMMATION, BUTYRYLCHOLINESTERASE, HYDROCHLORIDE, PURIFICATION, APOPTOSIS
  • Atatürk Üniversitesi Adresli: Evet

Özet

In this study, it was demonstrated the ameliorative effect of zingerone (ZO) (25 and 50 mg/kg body weight) against vancomycin (VCM) (200 mg/kg body weight) administered to rats on some metabolic enzymes' activities in the lung, liver, kidney, and testis tissues of rats. Forty-two rats were divided into six groups as follows: control, ZO-25, ZO-50, VCM, VCM + ZO-25, and VCM + ZO-50. alpha-Glycosidase, butyrylcholinesterase, aldose reductase, acetylcholinesterase, paraoxonase-1, and carbonic anhydrase enzyme activities were significantly (P < .05) decreased in VCM group when compared with the control group. ZO, supplied with VCM, significantly activated some of these enzyme in all tissues. The results of this study showed that ZO regulates abnormal increases and decreases in VCM-induced metabolic enzyme activities in all tissues.