Evaluation of the Effect of Asiatic Acid on Cerebral Vasospasm An Experimental Study

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Akyuz M. E., Şahin M. H., Kadıoğlu H. H.

ANALYTICAL AND QUANTITATIVE CYTOPATHOLOGY AND HISTOPATHOLOGY, cilt.43, sa.6, ss.633-640, 2021 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 43 Sayı: 6
  • Basım Tarihi: 2021
  • Dergi Adı: ANALYTICAL AND QUANTITATIVE CYTOPATHOLOGY AND HISTOPATHOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), BIOSIS
  • Sayfa Sayıları: ss.633-640
  • Anahtar Kelimeler: asiatic acid, subarachnoid hemorrhage, vasospasm, EXPERIMENTAL SUBARACHNOID HEMORRHAGE, NF-KAPPA-B, SPINAL-CORD-INJURY, ANTIINFLAMMATORY ACTIVITIES, CELL-DEATH, MODELS, INHIBITION, ISCHEMIA
  • Atatürk Üniversitesi Adresli: Evet

Özet

OBJECTIVE: To investigate the effect of asiatic acid

(AA) on vasospasm in an experimental model of sub‐

arachnoid hemorrhage (SAH).

STUDY DESIGN: Sixty male Wistar albino rats were

divided into 3 groups: Group I=control group (Group

Ia: anatomy study group, Group Ib: sham surgery

group), Group II=subarachnoid hemorrhage (SAH)

group (Group Iıa: decapitation 1 hour after SAH, Group

Iıb: decapitation 72 hours after SAH), Group III=drug

administration group (Group IIIa: AA given 1 hour

before SAH and decapitation 1 hour after SAH, Group

IIIb: AA given 1, 24, and 48 hours after SAH and

decapitation after 72 hours). The SAH was created with

single bleeding model. The AA was administered 30

mg/kg (single dose for group IIIa, 3‐dose for group IIIb,

intraperitoneally). Basilar artery (BA) lumen area, wall

thickness, arterial wall changes, endothelial apoptosis,

and DNA damage were evaluated in histopathological

sections.

RESULTS: The increased average wall thickness after

SAH was significantly reduced by AA treatment. In

the treatment group, the average lumen area of BA was

increased statistically significantly, and pathological

changes in the artery wall and endothelial DNA damage

and apoptosis were decreased or absent.

CONCLUSION: Findings in this study suggest that AA