Akademik Veri Yönetim Sistemi
KAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISI, cilt.22, sa.1, ss.119-125, 2016 (SCI-Expanded)
The aim of this study was to examine the effects of anabolic steroids on eccentric exercise-induced kidney tissue, using biochemical and histological methods. Sprague Dawley male rats (n= 36) were equally divided into the estrogen (17-beta Estradiol, 10 mg/kg per day)induced and non estrogen-induced groups. Both groups were subdivided into as rest groups (n= 6), and as exposed to the eccentric exercise groups (n= 12) that were also subdivided into decapitated one hour (n= 6) and 48 hour (n= 6) groups after eccentric exercise. Histopathological effects of estrogen treatment on eccentric exercise-induced rat kidney tissues were seen. The histopathological results revealed that hemorrhage, endothelium-dependent vasodilatations and degenerative changes in proximal tubules, glomeruli, and connective tissue in the estrogen-given and estrogen-given plus eccentric exercise groups. Distal tubule degenerations and dilatations with peritubular capillary dilatations and polymorphonuclear leucocyte (PMNL) infiltrations to connective tissue in eccentric exercise and eccentric exercise plus estrogen-given groups were detected but also it was noticeable decreases in PMNL infiltrations in estrogen-given groups. Biochemical results showed oxidative stress in experimental groups except Control group. It has been concluded that estrogen could not have been effective for preventing eccentric exercise-induced kidney damage and might have toxic effects on kidney tissues on clinical practice however anti-inflammatory effect on kidney tissue detected. It has been requested further investigation.