Akademik Veri Yönetim Sistemi
Turkish Journal of Medical Sciences, cilt.22, sa.3, ss.163-166, 1994 (SCI-Expanded)
The effects of octreotide (synthetic somatostatin analogue) on survival, fluid-electrolyte balance, and the gross and microscopic pathologic features of the intestinal wall in mice with mechanical intestinal obstruction are examined. Sixty-nine male mice weighing 22-28 g were divided into three groups, each containing 23 animals. Under ether anesthesia, the duodenojejunal junction (PO: proximal obstruction group) and the distal ileum (DO: distal obstruction group) were ligatured with a suture in the first and second groups, respectively, while a 20-cm length, closed-loop obstruction was performed in the distal ileum (LO: loop obstruction group) in the third group. Each of the groups was divided into two subgroups, each containing at least 9 animals, who received either octreotide (100 μg/kg, intraperitoneally) as the study group or saline solution (1.5 cc) as the control group every 8 hours. In groups PO and DO, the survival rate was determined. In group LO, the animals were killed and intestinal fluid volume and luminal sodium and postassium concentrations and outputs were measured. Octreotide significantly improved survival in group PO (P < 0.01), although this is less significant in group DO (P < 0.05). In group LO, significantly decreased intestinal luminal volume and luminal sodium and potassium outputs were observed with controls (P < 0.001); while there had been no difference in sodium and potassium concentrations (P > 0.05). In group LO, the histopathological examination of the intestinal wall showed less damage in the study group when compared with controls.