In vitro effects of some drugs on human red blood cell glucose-6-phosphate dehydrogenase enzyme activity

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Atıf İçin Kopyala

Ozdemir H., CIFTCI M.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, cilt.21, sa.1, ss.75-80, 2006 (SCI-Expanded)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 21 Sayı: 1
• Basım Tarihi: 2006
• Doi Numarası: 10.1080/14756360500356790
• Dergi Adı: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Sayfa Sayıları: ss.75-80
• Atatürk Üniversitesi Adresli: Evet

Özet

In vitro effects of omeprazole, morphine sulphate, remifentanyl, ketamine and vankomycin were investigated on human red blood cell glucose-6 phosphate dehydrogenase (G-6PD) (E.C. 1.1.1.49) enzyme activity purified from human red blood cell by 2', 5'ADP-Sepharose 4B affinity gel. The obtained 150 values of omeprazole, morphine, remifentanil, ketamine and vankomycin were 3.24, 43.58, 97.6, 64.16 and 0.903 mM, respectively and the K-i constants for omeprazole, morphine and vankomycin were 8.22 +/- 2.055, 25.93 +/- 6.482, and 2.71 +/- 0.677 mM, respectively and they were non competitive inhibitors.