Evaluation of the Potential in Vivo Genotoxicity of Tungsten (VI) Oxide Nanopowder for Human Health

Turkez H., Cakmak B., Celik K.

2nd International Conference on Materials and Applications for Sensors and Transducers, IC-MAST, Budapest, Macaristan, 24 - 28 Mayıs 2012, cilt.543, ss.89-92 identifier identifier

  • Yayın Türü: Bildiri / Tam Metin Bildiri
  • Cilt numarası: 543
  • Doi Numarası: 10.4028/www.scientific.net/kem.543.89
  • Basıldığı Şehir: Budapest
  • Basıldığı Ülke: Macaristan
  • Sayfa Sayıları: ss.89-92
  • Anahtar Kelimeler: Nanomaterial, Biosafety, Tungsten trioxide, In vivo, Risk Assesment, Genotoxicity, METAL-SALTS, INDUCTION
  • Atatürk Üniversitesi Adresli: Hayır

Özet

Tungsten (VI) oxide particles (WO3, <100 nm particle size) are used for many purposes including production of electro chromic windows, or smart windows, x-ray screen phosphors and gas sensors in everyday life. However, the carcinogenic and genotoxic potential of this nanomaterial have not been sufficiently evaluated. Therefore, the genotoxic potential of WO3 was examined in Sprague-Dawley rat bone marrow cells by using mitotic index (MI), micronucleus (MN) and chromosome aberrations (CA) assays. Rats were orally gavaged with a single dose of WO3 (0, 25, 50 and 100 mg/kg) for 30 days. All WO3 treatments significantly decreased MI rates as compared to the control group. No increase in the incidence of CA was observed at any WO3 nanoparticle dose in the CA test although MN formation was significantly (P<0.05) increased for 50 and 100 mg/kg doses. The observed alterations in MN and MI parameters reveal that WO3 has cytotoxic and genotoxic potential and could pose environmental and human health risk.