COVID-19 Disease and Vitamin D: A Mini-Review

Boulkrane M. S., Ilina V., Melchakov R., Fedotova J., Drago F., Gozzo L., ...Daha Fazla

Frontiers in Pharmacology, cilt.11, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 11
  • Basım Tarihi: 2020
  • Doi Numarası: 10.3389/fphar.2020.604579
  • Dergi Adı: Frontiers in Pharmacology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, EMBASE, Veterinary Science Database, Directory of Open Access Journals
  • Anahtar Kelimeler: SARS-CoV-2, COVID 19, respiratory tract infection, vitamin D3, vitamin D3 receptor, RENIN-ANGIOTENSIN SYSTEM, D SUPPLEMENTATION, IMMUNE-SYSTEM, 1,25-DIHYDROXYVITAMIN D-3, INFECTION, CATHELICIDIN, INFLUENZA, VIRUS, LL-37, DIFFERENTIATION
  • Atatürk Üniversitesi Adresli: Evet

Özet

© Copyright © 2020 Boulkrane, Ilina, Melchakov, Fedotova, Drago, Gozzo, Das, Abd El-Aty and Baranenko.Novel coronavirus disease (COVID-19) pandemic caused by SARS-CoV-2, for which there is no effective treatment except employing prevention strategies, has already instituted significant number of deaths. In this review, we provide a scientific view on the potential role of vitamin D in SARS-CoV-2 virus/COVID-19 disease. Vitamin D is well-known to play a significant role in maintaining the immune health of an individual. Moreover, it induces antimicrobial peptide expression that can decrease viral replication and regulate the levels of pro-inflammatory/anti-inflammatory cytokines. Therefore, supplementation of vitamin D has the potential to reduce the incidence, severity and the risk of death from pneumonia resulting from the cytokine storm of many viral infections including COVID-19. We suggest that supplementation of subjects at high risk of COVID-19 with vitamin D (1.000 to 3.000 IU) to maintain its optimum serum concentrations may be of significant benefit for both in the prevention and treatment of the COVID-19.