Correlation of diffusion MRI with the Ki-67 index in non-small cell lung cancer

Karaman A., Durur-Subası I., Alper F., Araz O., Subası M., Demırcı E., ...Daha Fazla

Radiology and Oncology, cilt.49, ss.250-255, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 49
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1515/raon-2015-0032
  • Dergi Adı: Radiology and Oncology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.250-255
  • Anahtar Kelimeler: diffusion weighted-magnetic resonance imaging, apparent diffusion coefficient, Ki-67 index, adenocarcinoma squamous cell carcinoma, WEIGHTED MRI, PULMONARY NODULES, COEFFICIENT, EXPRESSION, PREDICTION, PERFORMANCE, METASTASIS, SURVIVAL, MARKER, VALUES
  • Atatürk Üniversitesi Adresli: Evet

Özet

© 2015 Adem Karaman et al.Background. The primary objective of the study was to evaluate the association between the minimum apparent diffusion coefficient (ADCmin) and Ki-67, an index for cellular proliferation, in non-small cell lung cancers. Also, we aimed to assess whether ADCmin values differ between tumour subtypes and tissue sampling method. Methods. The patients who had diffusion weighted magnetic resonance imaging (DW-MRI) were enrolled retrospectively. The correlation between ADCmin and the Ki-67 index was evaluated. Results. Ninety three patients, with a mean age 65 ± 11 years, with histopathologically proven adenocarcinoma and squamous cell carcinoma of the lungs and had technically successful DW-MRI were included in the study. The numbers of tumour subtypes were 47 for adenocarcinoma and 46 for squamous cell carcinoma. There was a good negative correlation between ADCmin values and the Ki-67 proliferation index (r = -0.837, p < 0.001). The mean ADCmin value was higher and the mean Ki-67 index was lower in adenocarcinomas compared to squamous cell carcinoma (p < 0.0001). There was no statistical difference between tissue sampling methods. Conclusions. Because ADCmin shows a good but negative correlation with Ki-67 index, it provides an opportunity to evaluate tumours and their aggressiveness and may be helpful in the differentiation of subtypes non-invasively.