Akademik Veri Yönetim Sistemi
3. International Conference on Agriculture, Food, Veterinary and Pharmacy Sciences, Trabzon, Türkiye, 16 - 18 Nisan 2019, ss.344-348
Helichrysum plicatum subsp. plicatum (Asteraceae) is known as “ölmez
çiçek, altın otu” in Turkey. As the capitulums of the plant are rich from flavonoids
and have high antioxidant activity, one may expect high tyrosinase inhibitory
activity for this drog. Tyrosinase is a key enzyme involved in the melanin synthesis
pathway. While high tyrosinase activities may lead to hyperpigmentation in
humans, blacking in fruits and vegetables; the low tyrosinase activities may
lead to hypopigmentation in humans. In addition, melanin has also found in the
brain and has crucial roles in the nervous system and thus its extreme
production may cause to neurodegeneration. Four different extracts were
fractionated from the crude methanol extract and tyrosinose inhibition activity
values were determined. N-hexan, water, dichloromethane, ethyl
acetate extract and commercial α-Kojic
acid tyrosinose inhibition activity values were % 63, 33, 30, 1.18, 90 at 50 μg/mL,
respectively. According to results n-hexan extracts showed the highest
tyrosinase inhibitory effects.
Keywords: Helichrysum plicatum subsp. plicatum, tyrosinase, cosmetics