Treatment of Isolated Cataplexy With Low-dose Aripiprazole in an Adolescent Patient

Uzun N., Akinci M. A.

CLINICAL NEUROPHARMACOLOGY, cilt.43, sa.4, ss.125-126, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 43 Sayı: 4
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1097/wnf.0000000000000398
  • Dergi Adı: CLINICAL NEUROPHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE, MEDLINE, MLA - Modern Language Association Database, Psycinfo
  • Sayfa Sayıları: ss.125-126
  • Anahtar Kelimeler: isolated cataplexy, narcolepsy, aripiprazole, adolescent, NARCOLEPSY, DISORDER, DR2
  • Atatürk Üniversitesi Adresli: Evet

Özet

Background Cataplexy is a clinical entity that is characterized by transient muscle tone loss that mostly occurring as a part of narcolepsy. On the other hand, isolated cataplexy (IC) (hereditary cataplexy) is defined as loss of muscle tone that is not accompanied by narcolepsy. Emotional reactions may trigger IC episodes. Additionally, human leukocyte antigen (HLA) DQB1 alleles were shown to be related to IC. Various antidepressants are useful in the treatment of IC; however, there is limited knowledge on the use of antipsychotics in the treatment of IC. Case Report A 16-year-old adolescent girl was consulted child and adolescent psychiatry outpatient clinic with complaint of sudden episodes of loss of muscle tone. Her HLA typing showed HLA DQB1*03 haplotype. She was diagnosed with IC and was prescribed aripiprazole 2.5 mg/d and her IC symptoms disappeared and never recurred over 6 months of follow-up. Conclusions In this case report, we present an adolescent girl with IC that is successfully treated with aripiprazole, an antipsychotic. This case report suggests that aripiprazole may be safely used in some adolescents who diagnosed with IC.