Akademik Veri Yönetim Sistemi
30. Ulusal Çocuk ve Ergen Ruh Sağlığı ve Hastalıkları Kongresi, Ankara, Türkiye, 20 - 22 Mayıs 2021, ss.286, (Özet Bildiri)
P19 - A Case of KBG syndrome
Müberra KOLAK1
, Hicran DOĞRU 1
, İbrahim Selçuk ESİN1
,
1Atatürk Üniversitesi Çocuk Psikiyatri Anabilim Dalı,
İNTRODUCTİON:KBG syndrome is a rare disorder that affects several body systems which is characterized by
macrodontia of upper central incisors, distinctive craniofacial features such as the triangular face, prominent nasal
bridge, thin upper lip, and synophrys, skeletal findings including short stature delayed bone age and costovertebral
anomalies, and developmental delay/intellectual disability, sometimes associated with seizures and EEG
abnormalities(1). The behavioral issues (autistic findings, masturbating, self-injuring, etc.) are common among
patients with KBG syndrome which is associated with ANKRD11genes. Case : A 12-year-old male patient with
mild mental retardation who lived with his family was admitted to our outpatient psychiatry outpatient clinic with
complaints of hyperactivity and behavioral disorder that persisted for approximately one year. The patient was
diagnosed with known epilepsy and in 2016, molecular diagnosis of KBG syndrome. In terms of neurology, he
had no history of seizures for about a year and was being followed without medication. The patient had self- and
environment-damaging behavior, masturbatory movements, and profanity. In order to treat the patient's behavior
disorder, the patient was planned to begin aripiprazole treatment by slow titration. The patient was started on
aripiprazole (1 mg/day). After 1 week, he was called for control. When the patient came for control, he stated that
he had a seizure after using the family medicine. The treatment was stopped. Discussion: Antipsychotic drugs have
been found to increase the risk of epileptic seizures. Among the second-generation antipsychotics, the use of
clozapine carries the highest risk of seizure induction, while risperidone, quetiapine, amisulpride, and aripiprazole
represent a significantly lower risk. Our patient had seizures despite low titration. This shows us that the risk of
seizures should be considered when starting aripiprazole treatment in KBG syndrome and care should be taken
when adjusting the dose.
ANAHTAR KELİMELER: KBG syndrome, Aripiprazole, epileptic seizure, behavioural disorder