Alpha-Lipoic Acid Protects against Indomethacin-Induced Gastric Oxidative Toxicity by Modulating Antioxidant System

Kaplan K. A., Odabasoglu F., HALICI Z., Halici M. B., ÇADIRCI E., Atalay F., ...More

JOURNAL OF FOOD SCIENCE, vol.77, no.11, 2012 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 77 Issue: 11
  • Publication Date: 2012
  • Doi Number: 10.1111/j.1750-3841.2012.02920.x
  • Journal Name: JOURNAL OF FOOD SCIENCE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: alpha-lipoic acid, antioxidant enzymes, indomethacin, myeloperoxidase, LIPID-PEROXIDATION, MUCOSAL DAMAGE, INJURY, RATS, ERYTHROPOIETIN, INHIBITION, STRESS, TISSUE, CELLS, ASSAY
  • Ataturk University Affiliated: Yes

Abstract

Gastroprotective effects of alpha-lipoic acid (ALA) against oxidative gastric damage induced by indomethacin (IND) have been investigated. All doses (50, 75, 100, 150, 200, and 300 mg/kg body weight) of ALA reduced the ulcer index with 88.2% to 96.1% inhibition ratio. In biochemical analyses of stomach tissues, ALA administration decreased the level of lipid peroxidation (LPO) and activities of myeloperoxidase (MPO) and catalase (CAT) in gastric tissues, which were increased after IND application. ALA also increased the level of glutathione (GSH) and activities of superoxide dismutase (SOD) and glutathione S-transferase (GST) that were decreased in gastric damaged stomach tissues. In conclusion, the gastroprotective effect of ALA could be attributed to its ameliorating effect on the antioxidant defense systems.