Synthesis of 3,5-Diarylsubstituted İsoxazoles as an Anticancer Agent

Kaptan Y., Anıl D., Akınalp G., Karataş Ö. F., Burmaoğlu S., Algül Ö.

8. International Drug Chemistry Conference, Antalya, Türkiye, 27 Şubat - 01 Mart 2020, ss.201-205

  • Yayın Türü: Bildiri / Tam Metin Bildiri
  • Basıldığı Şehir: Antalya
  • Basıldığı Ülke: Türkiye
  • Sayfa Sayıları: ss.201-205
  • Atatürk Üniversitesi Adresli: Evet

Özet

In this work 3,5-diarylisoxazole derivatives was synthesized. The isoxazole precursor chalcone compounds were obtained by the Claisen Schmidt condensation reaction. Later, these chalcone derivatives were converted to isoxazole derivatives with TsNHOH reagent. Initially investigated the effects of the 3,5-diarylisoxazole compounds proliferation capacity of PC3 cells as an in vitro cancer model and PNT1a cells as corresponding normal control cells. Compound 26 distinguished from other compounds with a quite high specificity value that is comparable to 5-FU.