Current Status of COVID-19 Therapies and Drug Repositioning Applications

Altay O., Mohammadi E., Lam S., TÜRKEZ H., Boren J., Nielsen J., ...Daha Fazla

ISCIENCE, cilt.23, sa.7, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 23 Sayı: 7
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1016/j.isci.2020.101303
  • Dergi Adı: ISCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Directory of Open Access Journals
  • Atatürk Üniversitesi Adresli: Evet

Özet

The rapid and global spread of a new human coronavirus (SARS-CoV-2) has produced an immediate urgency to discover promising targets for the treatment of COVID-19. Drug repositioning is an attractive approach that can facilitate the drug discovery process by repurposing existing pharmaceuticals to treat illnesses other than their primary indications. Here, we review current information concerning the global health issue of COVID-19 including promising approved drugs and ongoing clinical trials for prospective treatment options. In addition, we describe computational approaches to be used in drug repurposing and highlight examples of in silico studies of drug development efforts against SARS-CoV-2.