Akademik Veri Yönetim Sistemi
JOURNAL OF ESSENTIAL OIL BEARING PLANTS, cilt.22, sa.3, ss.604-613, 2019 (SCI-Expanded)
This study was conducted to determine protective effects of thymol against non-steroidal anti-inflammatory drug induced damages on pancreas of rats. For this aim, thirty five Sprague-Dawley male rats were randomly allocated into five groups including control group, ketoprofen (Keto)-treated group (50 mg/kg) and the other three remaining groups received orally 100-400 mg/kg thymol before Keto administration, respectively. Thymol was orally administrated for 2 days before Keto administration, and continued for 4 days. To evaluate the antioxidative and anti-apoptotic effects of thymol against Keto induced damages in rat pancreatic cells, total antioxidant (TAS) and total oxidative stress (TOS) statuses, 8-hydroxy-20-deoxyguanosine (8-OHdG) levels and caspase-3 activities besides the histological features of the tissues were examined. The experimental data showed that Keto group, significantly increased the level of TOS, 8-OHdG and caspase-3 activation, while decreased level of TAS in tissue samples. On the other hand, because thymol exhibits strong antioxidant properties, Thymol treatment significantly decreased the level of TOS, 8-OHdG and caspase-3 activation, and ameliorated the pancreas histopathological changes induced by Keto. We found that thymol administration nearly eliminated Keto induced pancreatic damage.